The local application causes attenuation or disappearance of pain at the site of gel application, including joint pain at rest and in motion, decreases morning stiffness and swelling of joints. It boosts the volume of movements
When applying anavar vs winstrol a gel concentration of active substance in the systemic circulation is very low. The maximum concentration observed after a single application of the end of the first day, its value is more than 300 times lower than that for the oral dosage form of nimesulide. Traces of the main metabolite of nimesulide – 4 hydroxynimesulide in the blood can not be detected.
Local symptomatic treatment of diseases of the musculoskeletal system (joint syndrome in exacerbation of gout, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, low back pain with radicular syndrome, sciatica, inflammation of ligaments, tendons, bursitis, sciatica, lumbago). Muscle pain of rheumatic and rheumatic origin. Post-traumatic inflammation of soft tissue and musculoskeletal system (damages and torn ligaments, bruises).
: Hypersensitivity to nimesulide and the components of the drug; erosive and ulcerative lesions of the gastrointestinal tract in the acute stage, bleeding from the gastrointestinal tract, dermatitis, infections and damage to the epidermis of the skin in the area of application; severe renal (creatinine clearance less than 30 ml / min) or hepatic impairment, an indication of a history anavar vs winstrol of the phenomenon of bronchospasm associated with the use of aspirin, or other NSAIDs, pregnancy and lactation, children under 7 years.
Liver failure; renal failure; severe heart failure; arterial hypertension; type 2 diabetes; coagulation disorders, elderly and children’s age.
Dosing and Administration
NIMULID designed exclusively for outdoor use 3-4 times a day. In the area of maximum pain should be applied about 3 cm gel column NIMULID and easy movements of the fingers evenly distribute an even layer, without rubbing. After use, wash hands with soap and water. The amount and frequency of application of the gel (up to 4 times a day) may vary depending on the area to be treated and the patient’s response. Do not apply the gel more than 10 days without consulting a doctor.
Local reactions:. Itching, rash, peeling, transient changes in skin color (which does not require discontinuation of the drug)
If there are any adverse reactions should stop using the product and consult a physician. When applying the gel to the extensive areas of the skin or prolonged use, it is possible the development of systemic adverse reactions, heartburn, nausea, vomiting, diarrhea, gastralgia, ulceration of the mucous membrane of the gastrointestinal tract, increased activity of “liver” transaminases; headache, dizziness; fluid retention, hematuria; allergic reactions (anaphylaxis, skin rash); thrombocytopenia, leukopenia, anemia, agranulocytosis, prolongation of bleeding time.
Cases of overdose have not been described. However, when applying large amounts of gel (in excess of 50 g) to the vast areas of the skin it is possible overdose development. There is no specific antidote.It is necessary to consult a doctor.
Interaction with other drugs
is possible pharmacokinetic interaction with drugs competing for the connection to anavar vs winstrol plasma proteins.
It is necessary to be careful while applying the gel NIMULID with digoxin, phenytoin, lithium medications, diuretics, cyclosporine, methotrexate, other NSAIDs, hypotensive and hypoglycemic agents.
Before using the gel should consult with your doctor if you are using these funds or are under a doctor’s supervision.
nimulid can not be applied to mucous membranes, including the conjunctiva, as well as on areas of the skin affected with dermatosis or infections. Do not apply to open wounds and damaged skin. NIMULID should not strongly rubbed into the skin. The treated skin areas they can not close occlusive dressings. Tightly close the tube after use.