When assigning nimesulide in less than 24 hours before or after administration of methotrexate requires careful, since in such cases the MTX level in the plasma and, accordingly, the toxic effects of the drug may be increased. Due winstrol for women to the effect on renal prostaglandins, prostaglandin synthetase inhibitors, for what concerns the nimesulide may increase the nephrotoxicity of cyclosporin.
The interaction of other drugs with nimesulide:
In vitro studies showed that Nimesulide is displaced from the binding sites tolbutamide, salicylic acid and valproic acid. Despite the fact that these interactions have been identified in blood plasma, these effects have not been observed during clinical use of the drug.
The undesirable side effects can be minimized by using the minimum effective dose short course possible minimum. Winstrol for women should be used with caution in patients with gastrointestinal diseases in history (ulcerative colitis, Crohn’s disease) as these conditions may increase.
The risk of gastrointestinal bleeding, ulceration or perforation of the ulcer increases with the dose in patients with the presence of ulcers in the anamnesis, especially complicated by bleeding or perforation, as well as in elderly patients, so treatment should be started with the lowest possible dose. In patients receiving drugs that reduce blood clotting or inhibit platelet aggregation and increases the risk of gastrointestinal bleeding. In case of gastrointestinal bleeding or ulcers in patients taking , drug treatment should be discontinued.
Since partially excreted by the kidneys, its dosage for patients with impaired renal function should be reduced, depending on the level of urine. There is evidence of the occurrence of rare cases of reactions by the liver. When liver damage symptoms (itching, yellowing of the skin, nausea, vomiting, abdominal pain, dark urine, increased activity of “liver” transaminases) should stop taking the drug and consult a doctor. Despite the rare occurrence of visual impairment in patients taking nimesulide in conjunction with other NSAIDs, treatment should be discontinued immediately. If there is any violation of, the patient should inspect the eye doctor. The drug can cause fluid retention in the tissues, so patients with high blood pressure and disorders of cardiac activity should be used with extreme caution.
In patients with renal or heart failure drug use with caution, because the possible deterioration of renal function. In the case of deterioration, the treatment should be discontinued drug Nimesil.Clinical trials and epidemiological evidence suggests that NSAIDs, especially at high doses and for prolonged use may lead to a slight risk of myocardial infarction or stroke. To eliminate the risk of such events in the application of nimesulide insufficient data. The product contains sucrose, it should be considered for patients suffering from diabetes (0.15-0.18 XE 100 mg) and those who observe low-calorie diet. Is not recommended for patients with rare hereditary disorders of fructose intolerance, galactose malabsorption glyukozy- or failure of sucrose-isomaltose.
In the event of signs of “cold” or acute respiratory viral infections during treatment with receiving the drug should be discontinued. Do not use concurrently with other NSAIDs.
Nimesulide can change the properties of platelets, so caution should be exercised when using winstrol for women the drug in patients with hemorrhagic diathesis, but the drug does not replace the prophylactic effect of aspirin in cardiovascular diseases.
Elderly patients are particularly susceptible to adverse reactions to NSAIDs, including the risk of gastrointestinal bleeding and perforation, threatening the patient’s life, worsening of renal function, liver and heart. When receiving the drug for such patients requires a proper clinical monitoring.
Like other class of NSAID drugs that inhibit prostaglandin synthesis, nimesulide may adversely affect the course of pregnancy and / or embryo development and can lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery, renal dysfunction, which may progress to renal failure with oligogidramniey to increase the risk of bleeding, reduction in uterine contractility, the emergence of peripheral edema. Therefore, nimesulide is contraindicated in pregnancy and lactation. Application of medication can negatively affect female fertility and is not recommended for women planning pregnancy. When planning a pregnancy should consult with a physician.
There is evidence of the occurrence of a rare skin reactions (such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) on nimesulide as well as to other NSAIDs. At the first sign of skin rash, mucosal lesions or other signs of allergic reaction to the drug receiving winstrol for women should be discontinued.
Effect on ability to drive vehicles and management mechanisms
Effect of the drug on the ability to drive vehicles and management mechanisms have not been studied, so the period of treatment should be careful when driving and other activities potentially hazardous activities that require high concentration and speed of psychomotor reactions. eminence labs