Venodilatiruyuschee agent from the group of nitrates. Nitrates are capable of releasing from the molecule nitric oxide, which is a natural endothelial relaxing factor – mediated winstrol dosage direct activation of soluble guanylate cyclase. Increasing the concentration of cGMP leads to a relaxation of smooth muscle fibers, mainly of venules and veins. It has antianginal and antispasmodic, relaxes the smooth muscles of the vascular walls, bronchi, gastrointestinal tract, biliary tract, ureter. For intravenous (i / v) administration provides a rapid decrease in preload on the heart due to the expansion of peripheral veins.
Reduces blood flow to the right atrium, helps reduce the pressure in the pulmonary circulation and the regression of symptoms of pulmonary edema, reduced afterload, myocardial oxygen demand (for by reducing preload and afterload ventricular wall voltage due to the reduced volume of the heart). It promotes redistribution of coronary blood flow in the area with reduced blood circulation.
It has a central inhibitory effect on sympathetic vascular tone, inhibiting the formation of the vascular component of pain. It causes dilation of meningeal blood vessels, which explains the headache if it is applied.
Acute myocardial infarction (including complicated by acute left ventricular failure); unstable angina, pulmonary edema, treatment of angina.
Hypersensitivity to the drug and other nitro compounds, collapse under the age of 18 years (effectiveness and safety has not been established).
Precautions (comparing the benefit / risk) – cranial hypertension, cardiac tamponade, toxic winstrol dosage pulmonary edema, hemorrhagic stroke, isolated mitral stenosis, aortic stenosis, hypertrophic obstructive cardiomyopathy, constrictive pericarditis, uncontrolled hypovolemia with normal or low pressure in the pulmonary artery in patients with heart failure, hypotension, low systolic blood pressure (BP) (may aggravate the condition, causing a paradoxical bradycardia and angina), glaucoma (risk of increased intraocular pressure), pregnancy (action category on the fetus C), lactation, shock (in tonnes. h. cardiogenic, except with high-pressure filling of the left ventricle, including secured intra-aortic counterpulsation or positive inotropic drugs with action), bleeding in the brain, recently transferred head trauma, pronounced cerebral atherosclerosis, acute myocardial infarction and heart failure with low-pressure filling of the left ventricle, severe renal insufficiency (risk of methemoglobinemia), thyrotoxicosis, severe anemia, liver failure, old age.
DOSAGE AND ADMINISTRATION:
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Treatment should be carried out with individual selection of the speed I / O administration. The solution was administered through an automatic dispenser or via infusion pump, allow to inject precise dosing solution and the rate of introduction of the total dose. Automatic dispenser allows entry even undiluted solution with 0.1% precise dosing rate and total dose administration.
The introduction through a conventional system for transferring liquids provides the precise dose by counting the number of drops of liquid transfused, nitroglycerin solution for this pre-diluted solution of 0.9% sodium chloride or 5% dextrose (glucose) – do not use any other solvent – at a concentration of 0.01% nitroglycerin. The selection of dose and rate of administration is carried out individually depending on blood pressure (BP), heart rate (HR), central venous pressure, ECG, and other factors.
When used from PVC tubing active substance absorbed and loss at the tube walls are from 40 to 80 % (it is advisable to use plastic and glass tubes). The solution is quickly destroyed in the light, so the bottles and system for transfusion must be winstrol dosage screened with opaque material. steroiden kaufen
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