Hypersensitivity to the drug, erosive and ulcerative lesions of the gastrointestinal tract (exacerbation), bleeding from the gastrointestinal tract; indication of a history of bronchospasm, urticaria or acute rhinitis associated with the use winstrol v of aspirin, NSAIDs; liver failure; renal insufficiency (creatinine clearance less than 30 ml / min, confirmed hyperkalemia), severe heart failure expressed by the human blood clotting, since the coronary artery bypass surgery, pregnancy, lactation, children under 12 years.
Ischemic heart disease, cerebrovascular disease, congestive heart failure, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, creatinine clearance less than 60 mL / min. A history of the development of ulcerative lesions gastrointestinal tract, the presence of infection Helicobacter pylori, old age, long-term use of NSAIDs, frequent alcohol consumption, severe somatic diseases, concomitant therapy following medications:
- anticoagulants (eg, warfarin)
- antiplatelet agents (eg, aspirin, clopidogrel)
- oral steroids (e.g., prednisolone)
- selective serotonin reuptake inhibitor (such as citalopram, fluoxetine, paroxetine, sertraline)
Dosage and administration
Adults and children over 12 years (body weight 40 kg) prescribed tablets 1 tablet 2 times a day.
Tablets are taken after a meal with sufficient water. The maximum daily dose of 200 mg.
Cardiovascular system: Infrequent – hypertension; -tahikardiya rarely, hemorrhage, “hot flashes.” Senses : rarely – blurred vision, very rarely – dizziness. Skin and mucous membranes : rarely – itching, rash, increased sweating; rare: erythema, dermatitis; very rare: urticaria, angioneurotic edema, swelling of the face, erythema multiforme, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome). Liver and biliary system : often – increase in “liver” transaminase; very rarely – hepatitis, fulminant hepatitis, jaundice, cholestasis. Kidneys and mochevyvodyashaya system : Infrequent – edema; rarely – dysuria, hematuria, urinary retention, hyperkalemia; very rarely – renal failure, oliguria, interstitial nephritis. hemopoiesis organs : rarely – anemia, eosinophilia; -trombotsitopeniya very rarely, pancytopenia, purpura, prolonged bleeding. Allergic reactions : seldom – hypersensitivity reaction; rarely -manafilaktoidnye reaction. General reactions : rarely – weakness; very rarely – hypothermia. In the case of others, not mentioned above, side effects or worsening of your winstrol v health, please contact immediately your doctor.
Overdose symptoms : lethargy, drowsiness, nausea, vomiting. They are usually reversible when providing supportive care. There may be gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression. Treatment : symptomatic treatment requires patient and supportive care of him. No specific antidote. If an overdose occurs during the last 4 hours of necessary to induce vomiting, to provide reception of activated carbon (60-100 g per human adult), osmotic laxatives. Forced diuresis, hemodialysis is not effective because of the high regard with protein drug.
Interaction with other drugs
The action of medicines which reduce blood clotting, increases with their simultaneous use with nimesulide.
Nimesulide can reduce the effect of furosemide. It reduces the therapeutic effect of antihypertensive drugs. Nimesulide may increase the possibility of occurrence of side effects while taking methotrexate.
Lithium plasma levels increased while taking drugs lithium and nimesulide. Due to the high degree of binding to plasma proteins nimesulide patients who are simultaneously treated with hydantoin and sulfonamides should be under a doctor’s supervision, undergoing tests at short intervals. Nimesulide may increase the effects of cyclosporin on the kidney.
Use with corticosteroids, serotonin reuptake inhibitors increase the risk of gastrointestinal-bleeding.
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Nimesulide should be used with caution in patients who have had a tendency to bleeding, in patients with diseases of the upper gastrointestinal tract or in patients receiving drugs that reduce blood clotting, or drugs that inhibit platelet aggregation.
As nimesulide is partially excreted by the kidneys, dosage it to patients with impaired renal function should be reduced, depending on the level of urine. Taking into account the reports of violations of patients treated with other winstrol v, treatment should be stopped immediately if there is any violation of, and the patient should inspect the eye doctor.
The drug can cause fluid retention in the tissues, so patients with high blood pressure and disorders of the heart activities of Nimesulide should be used with extreme caution. Patients should undergo regular medical supervision if they take along with nimesulide medicines, which are characterized by the effect on the gastrointestinal tract. Patients, whose employment requires concentration (sustained attention), should know that the drug can cause drowsiness or dizziness.
To reduce the risk of adverse effects on the gastrointestinal tract to use the minimum effective dose as low as possible short course. how much to inject for weight loss
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