Nimiq is a non-steroidal anti-inflammatory agent (NSAID) class of sulfonanilides. Has anti-inflammatory, analgesic and antipyretic effect.
Nimisulid belongs to a new generation of winstrol, whose mechanism of action is associated with selective inhibition of cyclooxygenase II and the impact on a number of other factors: inhibition of platelet activating factor, tumor necrosis factor alpha, and histamine inhibition of proteases.
The ingestion well absorbed from the gastrointestinal tract. The maximum concentration of the active substance in the blood plasma is reached after 1.5-2.5 hours after dosing. Use of the drug simultaneously with food reduces the rate of absorption, but not affecting its degree. Plasma protein binding is 99%, the volume of distribution – 0,19-0,35 l / kg. Nimesulide is extensively metabolised in the liver to form several metabolites produced mainly in the urine (70%) and the feces (30%).
In patients with renal failure (creatinine clearance of 30-80 ml / min) as well as in children and elderly patients pharmacokinetic profile of nimesulide has not changed significantly
Symptoms of fever associated with upper respiratory tract infections (viral or bacterial) and to relieve pain of various origins in the postoperative period, with injuries of the musculoskeletal system, with soft tissue injuries.
– Hypersensitivity to nimesulide and the components of the drug, acetylsalicylic acid or other NSAIDs
– “Aspirin” asthma
– gastric ulcer and duodenal ulcer in the acute phase of bleeding from the gastrointestinal tract,
– expressed human liver and kidney disease,
– pregnancy and lactation ,
– children up to age 12 years.
should be taken when winstrol appointing nimesulide in patients with impaired renal function, hypertension, heart failure, visual impairment, type 2 diabetes mellitus.
Due to the fact that when using the drug may cause side effects such as dizziness and somnolence, caution should be exercised when administered to patients involved in potentially hazardous activities that require high concentration and rapid mental and motor responses.
Interaction with other medicinal products
Caution should be exercised with concomitant use of nimesulide with:
– digoxin, phenytoin and lithium drugs
– diuretics and antihypertensive drugs
– other NSAIDs
– oral antidiabetic agents.
T. k. level of plasma protein binding increases the concentration of Nimesulide drugs competing with protein for communication.
Dosing and dosing regimen for adults: usually administered orally at a dose of 100 mg (2 tablets of 50 mg), 2 times after a meal. Children: 1.5 mg / kg body weight 2-3 times daily. The maximum dose for children should not exceed 5 mg / kg / day, divided into 2 or 3 doses. Tablets should be dissolved before use 5 ml (1 tsp) of water.
usually winstrol drug does not cause side effects. In rare cases, there may be ulceration of the gastrointestinal mucosa, fluid retention, nausea, vomiting, stomach pain, diarrhea, dizziness, drowsiness, itching, allergic reactions (skin rash, anaphylactic shock); thrombocytopenia, leukopenia, anemia, agranulocytosis; increased activity of “liver transaminases”; prolonged bleeding; hematuria.
If you notice any side effects, stop taking the drug and consult a doctor.
Cases of overdose have not been described. There is no specific antidote.
tablets dispersible 50mg, 100mg.
10 tablets in blister Al / Al of 50 and 100 mg. 2 or 10 blisters in a cardboard box with instructions for use.
Oral suspension 50 mg / 5 ml.
To 30 ml of the drug in a bottle of dark glass, a sealed aluminum screw-on lid. 1 bottle with instruction on use and dimensional cap is placed in a carton pack. massbol?